Effect of blood pressure control on the risk of proteinuria during bevacizumab treatment in patients with colorectal cancer: a single-center retrospective cohort study

Autor: Satoru Nihei, Junichi Asaka, Mizunori Yaegashi, Koichi Asahi, Kenzo Kudo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Pharmaceutical Health Care and Sciences, Vol 10, Iss 1, Pp 1-12 (2024)
Druh dokumentu: article
ISSN: 2055-0294
DOI: 10.1186/s40780-024-00372-8
Popis: Abstract Purpose Pre-existing hypertension is reportedly a major risk factor for bevacizumab-induced proteinuria. However, few studies have focused on the effects of blood pressure (BP) control on proteinuria during bevacizumab treatment. We report a retrospective study of the association between poor BP control and the risk of developing proteinuria in patients with colorectal cancer (CRC). Methods Data for CRC patients who received bevacizumab between April 2015 and March 2022 were retrospectively collected. Patients were categorized into two groups based on average systolic blood pressure (SBP) during treatment: normal SBP (
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