Clinical, laboratorial and radiographic predictors of Bordetella pertussis infection

Autor: Camila Vieira Bellettini, Andressa Welter de Oliveira, Cintia Tusset, Ludmila Fiorenzano Baethgen, Sérgio Luís Amantéa, Fabrizio Motta, Aline Gasparotto, Huander Felipe Andreolla, Alessandro C. Pasqualotto
Jazyk: English<br />Spanish; Castilian<br />Portuguese
Rok vydání: 2014
Předmět:
Zdroj: Revista Paulista de Pediatria, Vol 32, Iss 4, Pp 292-298 (2014)
Druh dokumentu: article
ISSN: 1984-0462
0103-0582
DOI: 10.1590/S0103-05822014000400003
Popis: OBJECTIVE: To identify clinical, laboratorial and radiographic predictors for Bordetella pertussis infection.METHODS: This was a retrospective study, which analyzed medical records of all patients submitted to a molecular dignosis (qPCR) for B. pertussis from September 2011 to January 2013. Clinical and laboratorial data were reviewed, including information about age, sex, signs/symptoms, length of hospitalization, blood cell counts, imaging findings, coinfection with other respiratory pathogens and clinical outcome.RESULTS: 222 cases were revised. Of these, 72.5% had proven pertussis, and 60.9% were under 1 year old. In patients aging up to six months, independent predictors for B. pertussisinfection were (OR 8.0, CI 95% 1.8-36.3; p=0.007) and lymphocyte count >104/µL (OR 10.0, CI 95% 1.8-54.5; p=0.008). No independent predictors of B. pertussisinfection could be determined for patients older than six months. Co-infection was found in 21.4% of patients, of which 72.7% were up to six months of age. Adenovirus was the most common agent (40.9%). In these patients, we were not able to identify any clinical features to detect patients presenting with a respiratory co-infection, even though longer hospital stay was observed in patients with co-infections (12 vs. 6 days; p=0.009).CONCLUSIONS: Cyanosis and lymphocytosis are independent predictors for pertussis in children up to 6 months old.
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