Differential Serum and Urine CRP, IP-10, and TRAIL Levels in Pediatric Urinary Tract Infection

Autor: Liat Ashkenazi-Hoffnung, Gilat Livni, Oded Scheuerman, Itay Berger, Eran Eden, Kfir Oved, Liran Shani, Gali Kronenfeld, Einav Simon, Olga Boico, Roy Navon, Tanya M. Gottlieb, Eran Barash, Meital Paz, Yael Yuhas, Eva Berent, Shai Ashkenazi
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Pediatrics, Vol 9 (2021)
Druh dokumentu: article
ISSN: 2296-2360
DOI: 10.3389/fped.2021.771118
Popis: Background: It is estimated that clinical evaluation and urinalysis are unable to diagnose >10% of urinary tract infections (UTI) in young children. TNF-related apoptosis induced ligand (TRAIL), interferon gamma induced protein-10 (IP-10), and C-reactive protein (CRP) exhibit differential expression in the blood in response to bacterial vs. viral infection. We assessed if the urinary and serum levels of these host biomarkers discriminate UTI, nephronia, and response to antibiotic treatment.Methods: Hospitalized febrile children aged
Databáze: Directory of Open Access Journals