ASSOCIATION OF CLINICAL AND GENETIC FACTORS WITH LEFT VENTRICLE HYPERTROPHY IN ARTERIAL HYPERTENSION
| Autor: | T. Yu. Kuznetsova, D. V. Gavrilov, L. M. Samohodskaya, D. V. Rebrikov, S. A. Morozova, P. I. Makarevich, A. V. Kolotvin, A. B. Balatsky, A. Yu. Postnov, S. A. Boitsov |
|---|---|
| Jazyk: | English<br />Russian |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Рациональная фармакотерапия в кардиологии, Vol 6, Iss 3, Pp 294-305 (2016) |
| Druh dokumentu: | article |
| ISSN: | 1819-6446 2225-3653 |
| DOI: | 10.20996/1819-6446-2010-6-3-294-305 |
| Popis: | Aim. To evaluate association of clinical and genetic factors with left ventricle hypertrophy (LVH) in patients with arterial hypertension (HT).Materials and methods. 672 patients with HT were involved, aged 50,6 y.o. in average, men 67%. Laboratory assays, ECG, echocardiography were performed. Control group included 184 healthy persons. Genotyping with single-nucleotide substitutions of the endothelial NO synthase (eNOS) Glu298Asp gene, the C242T of the NADPH oxidase p22phox subunit and the angiotensin 2 receptor type 1 А1166С gene was carried out using a polymerase chain reaction (PCR) with evaluating of restriction fragments length polymorphism, while with substitutions of the angiotensinogen М235Т, G(-6)A gene allele-specific PCR “in real time” was applied.Results. LVH was found in 39% of patients. It was more frequent in persons above 50 years old (OR 2,8, р |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|