Mapping the drivers of within-host pathogen evolution using massive data sets

Autor: Duncan S. Palmer, Isaac Turner, Sarah Fidler, John Frater, Dominique Goedhals, Philip Goulder, Kuan-Hsiang Gary Huang, Annette Oxenius, Rodney Phillips, Roger Shapiro, Cloete van Vuuren, Angela R. McLean, Gil McVean
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-10724-w
Popis: Various host factors may impact within-host pathogen evolution. Here, the authors develop a Bayesian approach for identifying host-pathogen interactions using large data sets of pathogen diversity, and apply it to investigate HLA-induced selection in the HIV-1 genome.
Databáze: Directory of Open Access Journals