Central Interleukin-1β Suppresses the Nocturnal Secretion of Melatonin
| Autor: | A. P. Herman, J. Bochenek, K. Król, A. Krawczyńska, H. Antushevich, B. Pawlina, A. Herman, K. Romanowicz, D. Tomaszewska-Zaremba |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Mediators of Inflammation, Vol 2016 (2016) |
| Druh dokumentu: | article |
| ISSN: | 0962-9351 1466-1861 |
| DOI: | 10.1155/2016/2589483 |
| Popis: | In vertebrates, numerous processes occur in a rhythmic manner. The hormonal signal reliably reflecting the environmental light conditions is melatonin. Nocturnal melatonin secretion patterns could be disturbed in pathophysiological states, including inflammation, Alzheimer’s disease, and depression. All of these states share common elements in their aetiology, including the overexpression of interleukin- (IL-) 1β in the central nervous system. Therefore, the present study was designed to determine the effect of the central injection of exogenous IL-1β on melatonin release and on the expression of the enzymes of the melatonin biosynthetic pathway in the pineal gland of ewe. It was found that intracerebroventricular injections of IL-1β (50 µg/animal) suppressed (P |
| Databáze: | Directory of Open Access Journals |
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