| Autor: |
Amit Benady, Sam J. Meyer, Eran Golden, Solomon Dadia, Galit Katarivas Levy |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Materials & Design, Vol 226, Iss , Pp 111605- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
0264-1275 |
| DOI: |
10.1016/j.matdes.2023.111605 |
| Popis: |
The advancement in additive manufacturing in recent years opened a new era for bone reconstruction methods, allowing for the design of customized implants that perfectly match clinical needs. This challenge is even more prominent in critical-sized bone defects, where the bone cannot heal independently. Here we present a novel workflow for such cases. First, a multidisciplinary team conducted the surgical plan, including the design of an intraoperative patient-specific instrument. Then, a Ti-6Al-4V implant was created to exactly fit the resected tumor's bone gap. An ambitious bone regenerative approach was taken in designing the implants with a porous-lattice body acting as a scaffold for new bone formation, reinforced with standard orthopedic instruments for adequate mechanical support. To prevent future failure of the implant, a finite element analysis was used to evaluate stress distribution simulation according to the multi-axis forces and moments applied on the bone during walking. Our results demonstrate the potential for Ti-6Al-4V implants to become the best practice for reconstructing significant bone defects. This proof-of-concept may enhance clinical care and catalyze new frontiers in patient-specific medicine. To the best of our knowledge, this is the first study to describe in detail the design and fabrication of this method. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full Text from ScienceDirect