Serum soluble Fas-ligand levels and flow-mediated vasodilation in patients undergoing peritoneal dialysis

Autor: Bülent Huddam, Alper Azak, Volkan Karakus, Alper Alp, Dilek Gibyeli Genek, Meral Gülay Kadioglu Kocak, Yelda Dere, Dilek Ersil Soysal, Murat Duranay
Jazyk: English<br />Ukrainian
Rok vydání: 2022
Předmět:
Zdroj: Український Журнал Нефрології та Діалізу, Iss 2(74) (2022)
Druh dokumentu: article
ISSN: 2304-0238
2616-7352
DOI: 10.31450/ukrjnd.2(74).2022.04
Popis: Abstract. Flow-mediated vasodilation (FMD) has been demonstrated to be a useful, non-invasive tool for the detection of endothelial dysfunction in atherosclerotic cardiovascular disease, the leading cause of mortality in end-stage kidney disease. The Fas/Fas ligand system of apoptosis resulting from activation of the caspase cascade- contributes to the pathophysiology of atherosclerosis. This ‘apoptotic’ system plays a central role in immune homeostasis. Vascular endothelial cells and inflammatory cells are the main resources of the Fas ligand. In this study, we aimed to investigate the role of soluble Fas ligand (sFasL) as a marker of FMD in peritoneal dialysis (PD) patients. Methods. A total of 43 patients undergoing maintenance PD and 40 healthy donors were enrolled in this cross-sectional observational study. Demographics, anthropometric measurements and clinical examinations were obtained. Endothelial function was evaluated by FMD of the brachial artery with high-resolution ultrasonography. Serum sFasL concentrations were measured with an enzyme-linked immunosorbent assay kit. Results. The enrolled partisipants were devited on 2 groups: PD patients who had been treated at least 12 weeks (group 1; mean age 41±14 years, M/F: 22/21) and gender matched 40 healthy controls (group 2; mean age 50±12 years, M/F: 19/20). The forearm FMD and serum sFasL levels were significantly lower in PD patients (3.95±2.01 vs 8.83 ± 6.17; p
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