Colorectal cancer‐initiating cells caught in the act

Autor: Sebastian M Dieter, Hanno Glimm, Claudia R Ball
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Zdroj: EMBO Molecular Medicine, Vol 9, Iss 7, Pp 856-858 (2017)
Druh dokumentu: article
ISSN: 20170785
1757-4676
1757-4684
DOI: 10.15252/emmm.201707858
Popis: Abstract Our increased awareness of the clonal organization of many hematological and solid cancers has dramatically changed our view on the design of novel therapeutic approaches for cancer. Tumor‐initiating cells (TIC) (a.k.a. cancer stem cells) are on the apex in this hierarchy and can self‐renew and differentiate, thereby continuously fueling tumor growth and metastasis formation. This process was previously thought to be unidirectional. Self‐renewing TIC therefore represent highly attractive targets for therapeutic intervention.
Databáze: Directory of Open Access Journals
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