First-trimester maternal renin-angiotensin-aldosterone system activation and the association with maternal telomere length after natural and IVF/ICSI conceived pregnancies: the Rotterdam periconception cohort

Autor: D. Aoulad Fares, R.E. Wiegel, A.J. Eggink, J.B.J. van Meurs, S.P. Willemsen, A.H.J. Danser, R.P.M. Steegers-Theunissen
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Hypertension in Pregnancy, Vol 42, Iss 1 (2023)
Druh dokumentu: article
ISSN: 1064-1955
1525-6065
10641955
DOI: 10.1080/10641955.2023.2238086
Popis: Objective To study associations between the first-trimester maternal determinants of renin-angiotensin-aldosterone system (RAAS) activation and telomere length (TL) in pregnancies conceived natural and after IVF/ICSI. Methods In 145 pregnancies of the Rotterdam Periconception cohort renin, prorenin and aldosterone concentrations were measured in maternal blood at 9 weeks gestational age (GA). TL was measured by qPCR at 20 weeks GA. Results A significantly negative correlation was found between renin and TL, which was attenuated for prorenin but not observed for aldosterone. Maternal TL was significantly shorter in pregnancies conceived after in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) compared to natural pregnancies. Conclusion The negative association between first-trimester maternal renin and maternal TL, and the shorter maternal TL in women after IVF/ICSI treatment compared to natural pregnancies, substantiates the role of excessive RAAS activation.
Databáze: Directory of Open Access Journals
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