| Autor: |
Li Huang, Mimi Tang, Kim Dalziel, Melanie Lloyd, Paxton Loke, Adriana C Lozinsky |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
BMJ Open, Vol 13, Iss 12 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2023-075521 |
| Popis: |
Objective To compared the cost-effectiveness of coadministration of a probiotic adjuvant with peanut oral immunotherapy (PPOIT) with placebo (no treatment) in children with peanut allergy.Design Prospectively planned cost-effectiveness analysis alongside a randomised control trial.Setting The Royal Children’s Hospital, Melbourne, Australia.Participants 56 children with peanut allergy aged 1–10 years at recruitment.Intervention A daily dose of probiotic Lactobacillus rhamnosus CGMCC 1.3724 (NCC4007) and peanut oral immunotherapy administered for 1.5 years.Main outcomes measures Costs were considered from a healthcare system perspective and included costs of treatment delivery and adverse events. Effectiveness outcomes included rate of sustained unresponsiveness (SU) and quality-adjusted life years (QALYs). The cost-effectiveness of PPOIT versus placebo was analysed using patient-level data. Time horizon was 10 years from commencement of PPOIT treatment, comprising 1.5 years of treatment (actual data), 4 years of post-treatment follow-up (actual data), and 4.5 years of extrapolation thereafter (modelling).Results Healthcare cost per patient over 10 years was higher for PPOIT compared with placebo ($A9355 vs $A1031, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
