| Autor: |
Yuan Zhang, Chunguang Shan, Weiwei Liu, Yaozhong Han, Guanggang Shi, Yongjian Ma, Kerstin Wagner, Xiaoyan Tian, Lili Zhang, Allan Joseph Larona, Steven Sacavage, Kathleen Franklin, Chengshuo Wang, Luo Zhang |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Allergy, Asthma & Clinical Immunology, Vol 18, Iss 1, Pp 1-10 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1710-1492 |
| DOI: |
10.1186/s13223-022-00686-y |
| Popis: |
Abstract Background Air pollution may induce or reinforce nasal inflammation regardless of allergy status. There is limited direct clinical evidence informing the treatment of airborne pollution-related rhinitis. Objective To assess the effectiveness of intranasal budesonide in adults with self-reported rhinitis symptoms triggered/worsened by airborne pollution. Methods Adults in northern China with self-reported rhinitis symptoms triggered or worsened by airborne pollution were randomized to budesonide 256 µg/day or placebo for 10 days in pollution season (October 2019 to February 2020). The primary endpoint was the mean change from baseline in 24-h reflective total nasal symptom score (rTNSS) averaged over 10 days. The secondary endpoints were subject-assessed Global Impression of Change (SGIC), mean change from baseline in individual nasal symptom severity, and mean change from baseline in individual non-nasal symptoms of cough and postnasal drip severity. One-sided P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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