Vitamin D deficiency in British South Asians, a persistent but avoidable problem associated with many health risks (including rickets, T2DM, CVD, COVID-19 and pregnancy complications): the case for correcting this deficiency

Autor: Barbara J Boucher
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Endocrine Connections, Vol 11, Iss 12, Pp 1-10 (2022)
Druh dokumentu: article
ISSN: 2049-3614
DOI: 10.1530/EC-22-0234
Popis: High vitamin D deficiency rates, with rickets and osteomalacia, have been common in South Asians (SAs) arriving in Britain since the 1950s with pre ventable infant deaths from hypocalcaemic status-epilepticus and cardiomyopathy. Vitamin D deficiency increases common SA disorders (type 2 diabetes and cardiovascular disease ), recent trials and non-linear Mendelian randomisation studies having shown deficiency t o be causal for both disorders. Ethnic minority, obesity, diabetes and social depriv ation are recognised COVID- 19 risk factors, but vitamin D deficiency is not, despite convin cing mechanistic evidence of it. Adjusting analyses for obesity/ethnicity abolishes vitam in D deficiency in COVID-19 risk prediction, but both factors lower serum 25(OH)D specifical ly. Social deprivation inadequately explains increased ethnic minority COVID-19 risks. SA vitamin D deficiency remains uncorrected after 70 years, official bodies using ‘educat ion’, ‘assimilation’ and ‘diet’ as ‘proxies’ for ethnic differences and increasing pressu res to assimilate. Meanwhile, English rickets was abolished from ~1940 by free ‘welfare foods ’ (meat, milk, eggs, cod liver oil), for all pregnant/nursing mothers and young children (
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