| Autor: |
Şentürk Hilal, Dedeakayoğulları Huri, Marion İlke U., Özçubukçu Salih, Kesici Mehmet S., Ünsal Beyge Şeyma, Acar Muradiye, Erkısa Genel Merve, Akbaş Fahri, Ulukaya Engin |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Türk Biyokimya Dergisi, Vol 49, Iss 4, Pp 542-550 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1303-829X |
| DOI: |
10.1515/tjb-2024-0123 |
| Popis: |
Human estrogen receptor alpha (ERα) is considered an important target, especially in the treatment of breast cancer, as it has a vital role in cancer development. ERα-targeted therapies generally target the ligand binding domain (LBD) of ERα. However, over time, cells develop resistance to this mechanism alternative approaches to inhibit ERα activity target ERα–DNA or ERα–cofactor interactions. Inhibitors of ERα–cofactor interactions are designed by targeting the hydrophobic hollow region of the receptor box LXXLL motif. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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