| Autor: |
Warren B Bilker, Lawrence N Shulman, Yehoda M Martei, Sonya Davey, Dipho I Setlhako, Tlotlo B Ralefala, Patrick Manshimba, Robert Gross, Angela DeMichele |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
BMJ Open, Vol 11, Iss 7 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2044-6055 |
| DOI: |
10.1136/bmjopen-2021-049574 |
| Popis: |
Objective Cancer drug stockouts occur at high frequencies globally, however, their effects on treatment are understudied in sub-Saharan Africa (SSA). We aimed to determine whether causes of suboptimal cancer treatment prescriptions differed between periods of stockout and full treatment supply.Design A retrospective cohort study of systemic therapy prescriptions for patients diagnosed with the twelve most common solid tumour cancers treated in 2016.Setting Princess Marina Hospital in Gaborone, Botswana.Participants Patients in the retrospective cohort who experienced any suboptimal treatment events, defined as ≥7 days delay or switch from guideline-concordant initiated therapy.Primary and secondary outcome measures Frequency of delays and patterns of prescription changes for specific regimens and cancer types.Results 167/378 patients contributed to 320 suboptimal events (115 therapy switches, 167 delays and 38 events with both), over 1452 total chemotherapy cycles received. Events during stockout were 43% delays, 43% switches and 14% both during stockout periods and 67.2% delays, 24.4% switches and 8.4% both during non-stockout periods (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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