Self-control is associated with health-relevant disparities in buccal DNA-methylation measures of biological aging in older adults

Autor: Y. E. Willems, A. deSteiguer, P. T. Tanksley, L. Vinnik, D. Fraemke, A. Okbay, D. Richter, G. G. Wagner, R. Hertwig, P. Koellinger, E. M. Tucker-Drob, K. P. Harden, Laurel Raffington
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-13 (2024)
Druh dokumentu: article
ISSN: 1868-7083
DOI: 10.1186/s13148-024-01637-7
Popis: Abstract Self-control is a personality dimension that is associated with better physical health and a longer lifespan. Here, we examined (1) whether self-control is associated with buccal and saliva DNA-methylation (DNAm) measures of biological aging quantified in children, adolescents, and adults, and (2) whether biological aging measured in buccal DNAm is associated with self-reported health. Following preregistered analyses, we computed two DNAm measures of advanced biological age (principal-component PhenoAge and GrimAge Acceleration) and a DNAm measure of pace of aging (DunedinPACE) in buccal samples from the German Socioeconomic Panel Study (SOEP-G[ene], n = 1058, age range 0–72, M age = 42.65) and saliva samples from the Texas Twin Project (TTP, n = 1327, age range 8–20, M age = 13.50). We found that lower self-control was associated with advanced biological age in older adults (PhenoAge Acceleration β = − .34, [− .51, − .17], p
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje