A unique class of Zn2+-binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile

Autor: Michael D. Sacco, Shaohui Wang, Swamy R. Adapa, Xiujun Zhang, Eric M. Lewandowski, Maura V. Gongora, Dimitra Keramisanou, Zachary D. Atlas, Julia A. Townsend, Jean R. Gatdula, Ryan T. Morgan, Lauren R. Hammond, Michael T. Marty, Jun Wang, Prahathees J. Eswara, Ioannis Gelis, Rays H. Y. Jiang, Xingmin Sun, Yu Chen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-022-32086-6
Popis: Antibiotics of the β-lactam class inhibit bacterial cell wall synthesis by targeting penicillin-binding proteins (PBPs). Here, Sacco et al. study the four PBPs present in the pathogen C. difficile, revealing unique structural features and shedding light on the mechanisms underlying β-lactam resistance in this organism.
Databáze: Directory of Open Access Journals
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