Ampicillin pharmacokinetics in azotemic and healthy dogs

Autor:	Kelly N. Monaghan, Mary Anna Labato, Mark G. Papich
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	acute kidney injury drug concentration half‐life plasma clearance volume of distribution Veterinary medicine SF600-1100
Zdroj:	Journal of Veterinary Internal Medicine, Vol 35, Iss 2, Pp 987-992 (2021)
Druh dokumentu:	article
ISSN:	1939-1676 0891-6640
DOI:	10.1111/jvim.16026
Popis:	Abstract Background Little is known about effects of factors such as kidney disease, affecting ampicillin pharmacokinetics in dogs. Objectives Determine the pharmacokinetics of ampicillin after a single intravenous dose in healthy and azotemic dogs. Animals Nine dogs presenting with acute kidney injury and 10 healthy dogs. Methods This was a prospective study. An ampicillin dose of 22.2 mg/kg (mean dose) was administered once intravenously. Blood samples were obtained at timed intervals (just before administration, 1, 2, 4, 12, and 24 hours), analyzed using high‐pressure liquid chromatography followed by pharmacokinetic analysis of the plasma drug concentrations. Results Peak ampicillin concentration (mcg/mL; 97.07 (36.1) vs 21.3 (50.26)), P
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b4720bb897dc48dea67a269bf85f9179 Zobrazit plný text záznamu Plný text View record in DOAJ