Ampicillin pharmacokinetics in azotemic and healthy dogs
Autor: | Kelly N. Monaghan, Mary Anna Labato, Mark G. Papich |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: | |
Zdroj: | Journal of Veterinary Internal Medicine, Vol 35, Iss 2, Pp 987-992 (2021) |
Druh dokumentu: | article |
ISSN: | 1939-1676 0891-6640 |
DOI: | 10.1111/jvim.16026 |
Popis: | Abstract Background Little is known about effects of factors such as kidney disease, affecting ampicillin pharmacokinetics in dogs. Objectives Determine the pharmacokinetics of ampicillin after a single intravenous dose in healthy and azotemic dogs. Animals Nine dogs presenting with acute kidney injury and 10 healthy dogs. Methods This was a prospective study. An ampicillin dose of 22.2 mg/kg (mean dose) was administered once intravenously. Blood samples were obtained at timed intervals (just before administration, 1, 2, 4, 12, and 24 hours), analyzed using high‐pressure liquid chromatography followed by pharmacokinetic analysis of the plasma drug concentrations. Results Peak ampicillin concentration (mcg/mL; 97.07 (36.1) vs 21.3 (50.26)), P |
Databáze: | Directory of Open Access Journals |
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