Dreamm-2: single-agent belantamab mafodotin in patients with relapsed/refractory multiple myeloma (rrmm), including subgroups with renal impairment (ri) and high-risk (hr) cytogenetics
| Autor: | S. Lonial, H.C. Lee, A. Badros, S. Trudel, A.K. Nooka, A. Chari, A-O. Abdallah, N.S. Callander, D.W. Sborov, A. Suvannasankha, K. Weisel, P.M. Voorhees, M. Hultcrantz, E.N. Libby, P.G. Richardson, P. Rodriguez Otero, B. Besemer, T. Facon, A. Hoos, J. Baron, T. Piontek, R.C. Jewell, E. Lewis, J. Opalinska, I. Gupta, A.D. Cohen, A. Medaglia |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Hematology Reports, Vol 12, Iss s1 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2038-8322 2038-8330 |
| Popis: | Introduction: Belanatamab mafodotin (GSK2857916; belamaf; BLENREP) showed deep and durable single-agent activity in the pivotal DREAMM-2 study primary analysis (NCT03525678)(1–5) in a patient population that historically has a poor prognosis (overall survival [OS] 6–9 months). This study aims to present longer-term efficacy/safety outcomes (13-month follow-up) with single-agent belamaf in DREAMM-2 in the overall patient population and patients with HR cytogenetics and RI, subgroups with poor outcomes. Methods: DREAMM-2 is an ongoing study of belamaf 2.5 mg/kg (n=97) or 3.4 mg/kg (n=99). Primary outcome: overall response rate (ORR; ≥partial response). In post-hoc analyses, HR-cytogenetics included t(4;14), t(14;16), 17p13del, or 1q21+. RI was based on estimated glomerular filtration rate (mild: ≥60– |
| Databáze: | Directory of Open Access Journals |
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