Frontotemporal dementia is the leading cause of 'true' A−/T+ profiles defined with Aβ42/40 ratio

Autor: Hélène Pouclet‐Courtemanche, Tri‐Bao Nguyen, Emilie Skrobala, Claire Boutoleau‐Bretonnière, Florence Pasquier, Elodie Bouaziz‐Amar, Edith Bigot‐Corbel, Susanna Schraen, Julien Dumurgier, Claire Paquet, Thibaud Lebouvier
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 11, Iss 1, Pp 161-169 (2019)
Druh dokumentu: article
ISSN: 2352-8729
21342644
DOI: 10.1016/j.dadm.2019.01.001
Popis: Abstract Introduction Patients with positive tauopathy but negative Aβ42 (A−T+) in the cerebrospinal fluid (CSF) represent a diagnostic challenge. The Aβ42/40 ratio supersedes Aβ42 and reintegrates “false” A−T+ patients into the Alzheimer's disease spectrum. However, the biomarker and clinical characteristics of “true” and “false” A−T+ patients remain elusive. Methods Among the 509 T+N+ patients extracted from the databases of three memory clinics, we analyzed T+N+ patients with normal Aβ42 and compared “false” A−T+ with abnormal Aβ42/40 ratio and “true” A−T+ patients with normal Aβ42/40 ratio, before CSF analysis and at follow‐up. Results 24.9% of T+N+ patients had normal Aβ42 levels. Among them, 42.7% were “true” A−T+. “True” A−T+ had lower CSF tauP181 than “false” A−T+ patients. 48.0% of “true” A−T+ patients were diagnosed with frontotemporal lobar degeneration before CSF analysis and 64.0% at follow‐up, as compared with 6% in the “false” A−T+ group (P < .0001). Discussion Frontotemporal lobar degeneration is probably the main cause of “true” A−T+ profiles.
Databáze: Directory of Open Access Journals
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