Durable response to EGFR tyrosine kinase inhibitors in a patient with non–small cell lung cancer harboring an EGFR kinase domain duplication
| Autor: | Esuteru Hirokawa, Satomi Watanabe, Kazuko Sakai, Masayuki Takeda, Chihiro Sato, Takayuki Takahama, Kazuto Nishio, Kazuhiko Nakagawa |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Thoracic Cancer, Vol 12, Iss 16, Pp 2283-2287 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1759-7714 1759-7706 |
| DOI: | 10.1111/1759-7714.14081 |
| Popis: | Abstract Epidermal growth factor receptor (EGFR) kinase domain duplication (KDD) has been identified as an oncogenic driver in 0.05% to 0.14% of non–small cell lung cancer (NSCLC) patients. However, little is known of the efficacy of EGFR tyrosine kinase inhibitors (TKIs) for such patients. Here, we report the case of a 45‐year‐old Japanese woman with NSCLC positive for EGFR‐KDD (duplication of exons 18–25) who developed carcinomatous meningitis and showed a marked response to the EGFR‐TKIs erlotinib and osimertinib. As far as we are aware, this is the first report of EGFR‐TKI efficacy for carcinomatous meningitis in a NSCLC patient harboring EGFR‐KDD. |
| Databáze: | Directory of Open Access Journals |
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