Identical and Nonidentical Twin Drugs
| Autor: | Rajić, Z., Huzjak, M., Zorc, B. |
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| Jazyk: | English<br />Croatian |
| Rok vydání: | 2008 |
| Předmět: | |
| Zdroj: | Kemija u Industriji, Vol 57, Iss 11, Pp 511-519 (2008) |
| Druh dokumentu: | article |
| ISSN: | 0022-9830 1334-9090 |
| Popis: | Twin drugs contain two pharmacophoric groups combined covalently in a single molecule. Pharmacophoric groups can be identical moieties (identical twin drugs) or different (nonidentical twin drugs). Identical twin drugs can act on receptors (biogenic amine receptors, peptide receptors, Ca2+channel, σ receptors in the brain, leukotriene B4 receptors), as enzyme inhibitors (HIVenzyme, protein kinase, prolyl hydrolase, acyl-CoA cholesterol acyl transferase, spermidine- spermine-N1-acetyltransferase, S-adenosylmethionine decarboxylase), and as DNA ligands. Nonidentical twin drugs exert their dual action on two different receptors, on two binding sites of a single receptor, on two enzymes, or on both a receptor and an enzyme. |
| Databáze: | Directory of Open Access Journals |
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