| Autor: |
Leila Rostamizadeh, Behzad Baradaran, Kobra Rostamizadeh, Ommoleila Molavi, Sahar Safaee, Seied Rafi Bahavarnia, Fatemeh Ramezani |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
ImmunoAnalysis, Vol 3, Iss 1, Pp 5-5 (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2783-2589 |
| DOI: |
10.34172/ia.2023.05 |
| Popis: |
Background: Recently, combination therapy has become a promising approach to overcoming chemotherapy problems. In the present study, we describe a combinational treatment regime using cisplatin (Cis) and imiquimod (IMQ) to increase the antitumor response of the therapy in A549 lung cancer cells. Methods: A549 cells were either treated with increasing concentrations of Cis or IMQ or with Cis-IMQ combinations for 24h. Cell growth inhibition, cell cycle analysis, and inductive apoptosis were evaluated using MTT assay and annexin V assay using flow cytometry, respectively. Kruskal-Wallis was used to analyze differences in cell groups’ means. Results: A549 cell viability was affected by single therapy of Cis and IMQ in a dose and time-dependent manner (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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