| Autor: |
Eric H.L. Lee, Raj Chari B.C., Andy Lam, Raymond T. Ng, John Yee, John English, Kenneth G. Evans, Calum Macaulay, Stephen Lam, Wan L. Lam |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Clinical Medicine Insights: Oncology, Vol 2 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1179-5549 |
| DOI: |
10.4137/CMO.S612 |
| Popis: |
Disruptions of beta-catenin and the canonical Wnt pathway are well documented in cancer. However, little is known of the non-canonical branch of the Wnt pathway. In this study, we investigate the transcript level patterns of genes in the Wnt pathway in squamous cell lung cancer using reverse-transcriptase (RT)-PCR. It was found that over half of the samples examined exhibited dysregulated gene expression of multiple components of the non-canonical branch of the WNT pathway. In the cases where beta catenin ( CTNNB1 ) was not over-expressed, we identified strong relationships of expression between wingless-type MMTV integration site family member 5A ( WNT5A )/ frizzled homolog 2 ( FZD2 ), frizzled homolog 3 ( FZD3 )/ dishevelled 2 ( DVL2 ), and low density lipoprotein receptor-related protein 5 ( LRP5 )/ secreted frizzled-related protein 4 ( SFRP4 ). This is one of the first studies to demonstrate expression of genes in the non-canonical pathway in normal lung tissue and its disruption in lung squamous cell carcinoma. These findings suggest that the non-canonical pathway may have a more prominent role in lung cancer than previously reported. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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