Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals
| Autor: | Rossana de Aguiar Cordeiro, Delia Jessica Astete-Medrano, Francisca Jakelyne de Farias Marques, Heuziwanne Tavares Leite Andrade, Lauro Vieira Perdigão Neto, Juliane Lira Tavares, Rita Amanda Chaves de Lima, Kharla Kharolyni Nobre Rabelo Patoilo, Andre Jalles Monteiro, Raimunda Sâmia Nogueira Brilhante, Marcos Fábio Gadelha Rocha, Zoilo Pires de Camargo, José Júlio Costa Sidrim |
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| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: | |
| Zdroj: | Memorias do Instituto Oswaldo Cruz, Vol 106, Iss 8, Pp 1045-1048 (2011) |
| Druh dokumentu: | article |
| ISSN: | 1678-8060 0074-0276 58229841 |
| DOI: | 10.1590/S0074-02762011000800024 |
| Popis: | The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii. |
| Databáze: | Directory of Open Access Journals |
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