Recent Advances in Pain Management: Relevant Protein Kinases and Their Inhibitors

Autor:	Francis Giraud, Elisabeth Pereira, Fabrice Anizon, Pascale Moreau
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	protein kinases inhibitors pain Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 9, p 2696 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26092696
Popis:	The purpose of this review is to underline the protein kinases that have been established, either in fundamental approach or clinical trials, as potential biological targets in pain management. Protein kinases are presented according to their group in the human kinome: TK (Trk, RET, EGFR, JAK, VEGFR, SFK, BCR–Abl), CMGC (p38 MAPK, MEK, ERK, JNK, ASK1, CDK, CLK2, DYRK1A, GSK3, CK2), AGC (PKA, PKB, PKC, PKMζ, PKG, ROCK), CAMK, CK1 and atypical/other protein kinases (IKK, mTOR). Examples of small molecule inhibitors of these biological targets, demonstrating an analgesic effect, are described. Altogether, this review demonstrates the fundamental role that protein kinase inhibitors could play in the development of new pain treatments.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b3f3145437ef407dacfb4b6e8ee3d16b Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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