| Autor: |
Dandan Cui, Jie Mi, Zhenhui Zhang, Xiaoye Su, Xiaodong Sun, Gen Mu, Yujiao Shi, Sihua Yang |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Photoacoustics, Vol 33, Iss , Pp 100546- (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2213-5979 |
| DOI: |
10.1016/j.pacs.2023.100546 |
| Popis: |
Photoacoustic (PA) theranostics is a new emerging field that uniquely combines diagnosis and treatment in one modality. However, its current status is compromised by the indispensable dependence on nonreversible phase-change nanoprobes that provides one-time-only action. Here, we demonstrate a picosecond-laser-pumped ultrafast PA cavitation technique for highly efficient shockwave theranostics, guaranteeing sustained PA cavitation by using non-phase-change nanoprobes. Theoretical simulations validate that, when compressing the excitation laser pulse width to hundred-picosecond, the thermal confinement effects of a conventional nanoprobe will induce transient heating of the extremely thin surrounding liquid layer of the nanoprobes beyond its cavitation point in a localized area at nanoscale, resulting in intense cavitation and PA shockwaves by the environment rather than the nanoprobes. Both cellular and mouse model experiments have demonstrated the highly effective anti-tumor effects. This method provides a sustainable, reproducible, and highly effective strategy for PA theranostics, prefiguring great potential for the clinical applications. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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