Noninvasive prediction of hepatitis C-associated hepatocellular carcinoma using circulating apolipoproteins

Autor: Hasan El Garem, Gamal Esmat, Rabab Salama, Hanan Fouad, Dina Sabry, Yomna Mostafa, Dalia Omran, Heba Omar
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: The Egyptian Journal of Internal Medicine, Vol 31, Iss 4, Pp 451-457 (2019)
Druh dokumentu: article
ISSN: 1110-7782
2090-9098
DOI: 10.4103/ejim.ejim_26_19
Popis: Background and aims Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. We investigated the potential usefulness of circulating apolipoproteins (Apo-A1 and Apo-A4) in HCC screening and diagnosis. Patients and methods We included 60 adult patients with hepatitis C virus-related chronic liver disease including HCC, in addition to 20 healthy controls. Patients were stratified into three equal groups, with 20 patients each: chronic hepatitis C, posthepatitis C cirrhosis (liver cirrhosis), and HCC. All patients and controls underwent full clinical assessment, laboratory investigations, and evaluation of candidate apolipoproteins by enzyme-linked immunoassay. Results Significantly higher Apo-A1 and Apo-A4 levels were detected in patients with HCC than in those with liver cirrhosis (P2 cm) than those with large tumors (P=0.01). Lower Apo-A1 level correlated significantly with pylethrombosis (P=0.007). Conclusion Apo-A1 and Apo-A4 are novel biomarkers for HCC screening and diagnosis, with a special discriminative ability for Apo-A1 for those with small tumors and those with pylethrombosis.
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