A case of severe nephrotic syndrome caused by isolated CMV glomerulopathy with ganciclovir resistant UL 97 mutation

Autor:	Ramez R. Sunna, Rupinder Sodhi, Francis Arden Purvis, Rosemary Ouseph, David S. Brink, Bahar Bastani
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	cmv glomerulopathy cmv viremia kidney transplant ul 97 mutation nephrotic syndrome proteinuria Pathology RB1-214 Internal medicine RC31-1245 Other systems of medicine RZ201-999
Zdroj:	Journal of Nephropathology, Vol 8, Iss 4, Pp e41-e41 (2019)
Druh dokumentu:	article
ISSN:	2251-8363 2251-8819
DOI:	10.15171/jnp.2019.41
Popis:	Introduction: While many cases of cytomegalovirus (CMV) nephropathy have been reported in the literature, isolated CMV glomerulopathy is considered a rare finding. Case Presentation: We report the case of a CMV-negative recipient of kidney allograft from a CMVpositive donor (D+/R-), the recipient subsequently developed severe nephrotic syndrome secondary to biopsy-proven isolated CMV glomerulopathy. Conclusion: The patient developed CMV viremia with ganciclovir resistant UL97 mutation. His treatment course was resistant to recommended dose of intravenous ganciclovir, so therapy was changed to foscarnet with resolution of his viremia and reduction in proteinuria.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/b3d51cc893664208bb4b7615ad03a1bc Zobrazit plný text záznamu View record in DOAJ