| Autor: |
Jun Hu, MD, John C. Krauss, MD, Micheline Moyal-Barracco, MD, Laraine L. Washer, MD, Hope K. Haefner, MD, Ebony Parker-Featherstone, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
International Journal of Women's Dermatology, Vol 7, Iss 5, Pp 731-736 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2352-6475 |
| DOI: |
10.1016/j.ijwd.2021.06.002 |
| Popis: |
Background: Vulvar pseudotumoral herpes infections have been reported in HIV-positive patients. A 32-year-old HIV-negative woman presented with a 6-month history of a vulvar pseudotumor that had been unresponsive to oral acyclovir and valacyclovir, as well as topical imiquimod. Objective: This study aimed to evaluate the therapeutic efficacy of a multidrug regimen for vulvar pseudotumor herpes infection in an HIV-negative patient. Methods: Histology revealed multinucleated giant cells, consistent with a herpes infection. The patient's herpes simplex virus type 2 was resistant to acyclovir. Immunomodulatory agents (thalidomide and topical imiquimod) were started. Results: The lesion enlarged after 6 weeks of treatment. Topical cidofovir 1% gel was added. There was gradual decrease in the pseudotumor size. After 7 months, the Pseudotumor had resolved. Conclusion: This is the first reported case of vulvar pseudotumoral herpes in an immunocompetent, HIV-negative patient. Oral thalidomide, in association with topical imiquimod and topical cidofovir, was effective in treating acyclovir-resistant pseudotumoral herpes of the vulva. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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