Extracellular Vesicles as Mediators of Neuroinflammation in Intercellular and Inter-Organ Crosstalk

Autor:	Andrea Cabrera-Pastor
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	extracellular vesicles exosomes neuroinflammation neurological disorders inter-organ crosstalk glial cells Biology (General) QH301-705.5 Chemistry QD1-999
Zdroj:	International Journal of Molecular Sciences, Vol 25, Iss 13, p 7041 (2024)
Druh dokumentu:	article
ISSN:	1422-0067 1661-6596
DOI:	10.3390/ijms25137041
Popis:	Neuroinflammation, crucial in neurological disorders like Alzheimer’s disease, multiple sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular vesicles (EVs) play a pivotal role in intercellular and inter-organ communication, influencing disease progression. EVs serve as key mediators in the immune system, containing molecules capable of activating molecular pathways that exacerbate neuroinflammatory processes in neurological disorders. However, EVs from mesenchymal stem cells show promise in reducing neuroinflammation and cognitive deficits. EVs can cross CNS barriers, and peripheral immune signals can influence brain function via EV-mediated communication, impacting barrier function and neuroinflammatory responses. Understanding EV interactions within the brain and other organs could unveil novel therapeutic targets for neurological disorders.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/cb3c8ef00e374bd5bda24511fa9ab48f Zobrazit plný text záznamu View record in DOAJ