Pharmacomechanical Thrombectomy Versus Catheter-Directed Thrombolysis for Iliofemoral Deep Vein Thrombosis: A Meta-Analysis of Clinical Trials

Autor: Tao Tang MD, Linyi Chen MD, Jinhui Chen MD, Tong Mei MD, Yongming Lu MD
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Clinical and Applied Thrombosis/Hemostasis, Vol 25 (2019)
Druh dokumentu: article
ISSN: 1938-2723
10760296
DOI: 10.1177/1076029618821190
Popis: Early catheter-directed thrombolysis (CDT) for deep vein thrombosis (DVT) can reduce postthrombotic morbidity. Pharmacomechanical thrombolysis (PMT) is a new therapy that can be selected for the treatment of iliofemoral deep vein thrombosis (IFDVT). We performed a meta-analysis of clinical trials comparing PMT versus CDT for treatment of acute IFDVT. Literature on this topic published between January 1, 1990, and June 1, 2018, was identified using PubMed, Embase, Cochrane Library, and Web of Science. Six trials were included in the meta-analysis. Compared to CDT, PMT significantly reduced the Villalta score ( P = .007; I 2 = 0%), thrombus score ( P = .01; I 2 = 0%), the duration in the hospital ( P = .03; I 2 = 64%), and thrombolysis time ( P < .00001, I 2 = 0%). There was no significant difference in valvular incompetence events ( P = .21; I 2 = 0%), minor bleeding events ( P = .59; I 2 = 0%), stent events ( P = .09; I 2 = 24%), and clot reduction grade I events ( P = .16; I 2 = 43%) between PMT and CDT. Subgroup analysis was performed by dividing the clot reduction grade I events group into PMT plus CDT versus CDT group and significant differences were found ( P = .03, I 2 = 0%) as well as for PMT alone versus CDT group ( P = .88, I 2 = 37%). This meta-analysis shows that PMT reduces the severity of postthrombotic syndrome (PTS), thrombus score, duration in hospital, and thrombolysis time compared to CDT. More specifically, PMT plus CDT reduces clot reduction grade I events. No significant difference in valvular incompetence events, stent events, and minor bleeding events were found when PMT was compared to CDT.
Databáze: Directory of Open Access Journals
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