Genomic Epidemiology of Multidrug-Resistant Nontyphoidal Salmonella in Young Children Hospitalized for Gastroenteritis

Autor: Pei Yee Woh, May Pui Shan Yeung, William Bernard Goggins, Norman Lo, Kam Tak Wong, Viola Chow, Ka Yee Chau, Kitty Fung, Zigui Chen, Margaret Ip
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Microbiology Spectrum, Vol 9, Iss 1 (2021)
Druh dokumentu: article
ISSN: 2165-0497
DOI: 10.1128/Spectrum.00248-21
Popis: ABSTRACT Nontyphoidal Salmonella (NTS) gastroenteritis in children remains a significant burden on health care and constitutes a majority of all admissions for Salmonella infections in public hospitals in Hong Kong. In this prospective study, 41% of 241 children hospitalized with gastroenteritis from three public hospitals during 2019 were culture confirmed to have NTS infection. These Salmonella isolates were whole-genome sequenced and in silico predicted for their serovars/serotypes using the Salmonella In Silico Typing Resource (SISTR) and SeqSero1, and the antimicrobial resistance (AMR) genes were determined. Phylogenetic analysis revealed three major clades belonging to Salmonella enterica serovar Enteritidis sequence type 11 (ST11) (43%), multidrug-resistant (MDR) S. Typhimurium ST19 (12%) and its monophasic variant ST34 (25%), and mostly singletons of 15 other serovars. MDR S. Typhimurium and its variant were more common in infants
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