Long-term effects on the progress of neuropathy after diabetic Charcot foot: an 8.5-year prospective case–control study

Autor: Rasmus Bo Jansen, Tomas Møller Christensen, Jens Bülow, Lene Rørdam, Per E. Holstein, Ole Lander Svendsen
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Zdroj: BMC Research Notes, Vol 11, Iss 1, Pp 1-6 (2018)
Druh dokumentu: article
ISSN: 1756-0500
DOI: 10.1186/s13104-018-3253-5
Popis: Abstract Objective Charcot foot is a severe complication to diabetes mellitus, associated with diabetic neuropathy. Any long-term effects of a Charcot foot on the progress of neuropathy are still largely unexplored. The objective was to investigate whether a previous Charcot foot had any long-term effects on the progress of neuropathy. Results An 8.5-year follow-up case–control study of 49 individuals with diabetes mellitus, 24 of whom also had Charcot foot at baseline visit in 2005–2007. Neuropathy was assessed with a questionnaire, biothesiometry, heart rate variability and venous occlusion plethysmography. Of the 49 baseline participants, 22 were able to participate in the follow-up. Twelve had passed away in the meantime. Heart rate variability was unchanged in both groups; from 9.7 to 7.2 beats/min (p = 0.053) in the Charcot group, and 14.3 to 12.6 beats/min (p = 0.762) in the control group. Somato-sensoric neuropathy showed no difference between baseline and follow-up in the Charcot group (from 39.1 to 38.5 V) (p = 0.946), but a significantly worsened sensitivity in the control group (from 25.1 to 38.9 V) (p = 0.002). In conclusion, we found that any differences in somatic or cardial autonomic neuropathy present at baseline had disappeared at follow-up after 8.5 years.
Databáze: Directory of Open Access Journals
Nepřihlášeným uživatelům se plný text nezobrazuje