| Autor: |
Rena Okuno-Ito, Masaaki Yamamoto, Yasunori Sato, Toru Serizawa, Jun Kawagishi, Takashi Shuto, Shoji Yomo, Atsuya Akabane, Kyoko Aoyagi, Takuya Kawabe, Yasuhiro Kikuchi, Kiyoshi Nakasaki, Masazumi Gondo, Yoshinori Higuchi, Toru Takebayashi |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Clinical and Translational Radiation Oncology, Vol 32, Iss , Pp 69-75 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2405-6308 |
| DOI: |
10.1016/j.ctro.2021.11.002 |
| Popis: |
Background and purpose: The Renal Graded Prognostic Assessment (GPA) is relatively new and has not been sufficiently validated using a different dataset. We thus developed a new grading index, the Renal Brain Metastasis Score (Renal-BMS). Materials and methods: Using our dataset including 262 renal cancer patients with brain metastases (BMs) undergoing stereotactic radiosurgery (SRS) (test series), we validity tested the Renal-GPA. Next, we applied clinical factor-survival analysis to the test series and thereby developed the Renal-BMS. This system was then validated using another series of 352 patients independently undergoing SRS at nine gamma knife facilities in Japan (verification series). Results: Using the test series, with the Renal-GPA, 95% confidence intervals (CIs) of the post-SRS median survival times (MSTs) overlapped between pairs of neighboring subgroups. Among various pre-SRS clinical factors of the test series, six were highly associated with overall survival. Therefore, we assigned scores for six factors, i.e., “KPS ≥ 80%/ |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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