| Autor: |
Nurul Syazrah Anuar, Hazmin Hazman, Sharven Raj Jeyakumar, Mohd Nasir Mohd Desa, Hasni Idayu Saidi, Siti Norbaya Masri, Nur Afiza Aziz, Nurshahira Sulaiman |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Asian Pacific Journal of Tropical Medicine, Vol 17, Iss 1, Pp 30-38 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2352-4146 |
| DOI: |
10.4103/apjtm.apjtm_303_23 |
| Popis: |
Objective: To determine the distribution, phenotypic and genetic background of extended spectrum β-lactamases (ESBL)-producing Klebsiella (K.) pneumoniae clinical isolates associated with K1 and K2 serotypes in two selected hospitals in Malaysia. Methods: A total of 192 K. pneumoniae isolates were collected and subjected to antibiotic susceptibility, hypermucoviscosity test and multiplex PCR to detect the presence of K1- and K2- serotype associated genes. Multilocus sequence typing (MLST) was performed on ESBL-producing K. pneumoniae isolates presented with K1 and K2 serotypes, followed by phylogenetic analysis. Results: A total of 87 out of 192 (45.3%) of the K. pneumoniae isolates collected were ESBL producers. However, only 8.3% (16/192) and 10.9% (21/192) of the total isolates were detected to carry K1- and K2-serotype associated genes, respectively. Statistical analysis showed that K1 and K2 capsular serotypes were not significantly associated with ESBL phenotype (P=0.196). However, they were significantly associated with hypervirulent, as demonstrated by the positive string test (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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