Association of visceral adiposity and insulin resistance with colorectal adenoma and colorectal cancer
| Autor: | In Sub Jung, Cheol Min Shin, Sung Jae Park, Young Soo Park, Hyuk Yoon, Hyun Jin Jo, Nayoung Kim, Dong Ho Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Intestinal Research, Vol 17, Iss 3, Pp 404-412 (2019) |
| Druh dokumentu: | article |
| ISSN: | 1598-9100 2288-1956 |
| DOI: | 10.5217/ir.2018.00072 |
| Popis: | Background/Aims To examine whether visceral adiposity serves as a risk factor for colorectal cancer (CRC) and colorectal adenomas. Methods Two hundred healthy subjects, 200 patients with colorectal adenoma, and 151 patients with CRC (46 with early-stage and 105 with advanced-stage cancers) were enrolled at a tertiary referral hospital. All subjects underwent colonoscopy, and had laboratory data, and computed tomography (CT) scan available for abdominal fat measurement. An abdominal CT scan taken 1 to 4 years (mean interval, 20.6 months) before the diagnosis of CRC was also available in the 42 CRC patients. Results The mean areas of visceral adipose tissue (VAT) areas in the control, adenoma, early- and advanced-stage CRC groups were 94.6, 116.8, 110.4, and 99.7 cm2, respectively (P0.05). The risk of both adenoma and CRC positively correlated with fasting plasma glucose levels (P for trend |
| Databáze: | Directory of Open Access Journals |
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