Are Hamsters a Suitable Model for Evaluating the Immunogenicity of RBD-Based Anti-COVID-19 Subunit Vaccines?

Autor: Iuliia A. Merkuleva, Dmitry N. Shcherbakov, Mariya B. Borgoyakova, Anastasiya A. Isaeva, Valentina S. Nesmeyanova, Natalia V. Volkova, Vazirbek S. Aripov, Daniil V. Shanshin, Larisa I. Karpenko, Svetlana V. Belenkaya, Elena I. Kazachinskaia, Ekaterina A. Volosnikova, Tatiana I. Esina, Alexandr A. Sergeev, Kseniia A. Titova, Yulia V. Konyakhina, Anna V. Zaykovskaya, Oleg V. Pyankov, Evgeniia A. Kolosova, Olesya E. Viktorina, Arseniya A. Shelemba, Andrey P. Rudometov, Alexander A. Ilyichev
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Viruses, Vol 14, Iss 5, p 1060 (2022)
Druh dokumentu: article
ISSN: 14051060
1999-4915
DOI: 10.3390/v14051060
Popis: Currently, SARS-CoV-2 spike receptor-binding-domain (RBD)-based vaccines are considered one of the most effective weapons against COVID-19. During the first step of assessing vaccine immunogenicity, a mouse model is often used. In this paper, we tested the use of five experimental animals (mice, hamsters, rabbits, ferrets, and chickens) for RBD immunogenicity assessments. The humoral immune response was evaluated by ELISA and virus-neutralization assays. The data obtained show hamsters to be the least suitable candidates for RBD immunogenicity testing and, hence, assessing the protective efficacy of RBD-based vaccines.
Databáze: Directory of Open Access Journals
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