| Autor: |
Hanping Li, Shuai Chang, Yang Han, Daomin Zhuang, Lin Li, Yongjian Liu, Siyang Liu, Zuoyi Bao, Wenfu Zhang, Hongbin Song, Taisheng Li, Jingyun Li |
| Jazyk: |
angličtina |
| Rok vydání: |
2016 |
| Předmět: |
|
| Zdroj: |
BMC Infectious Diseases, Vol 16, Iss 1, Pp 1-6 (2016) |
| Druh dokumentu: |
article |
| ISSN: |
1471-2334 |
| DOI: |
10.1186/s12879-016-1928-x |
| Popis: |
Abstract Background The widespread use of antiretroviral therapies has led to considerable concerns about the prevalence of drug-resistant, as transmission of drug-resistant (TDR) strains poses a challenge for the control of the HIV-1 epidemic. Methods We conducted an epidemiological study enrolling treatment-naïve HIV-1-positive subjects at the Peking Union Medical College Hospital since 1991. Drug resistance was determined by submitting the sequences to the Stanford University Network HIV-1 database. Results Of 521 participants, 478 samples were amplified and sequenced successfully. HIV Transmitted drug resistance prevalence in China was determined to be 6.7 %. We did not find significant differences in the TDR rate by demographic characteristics. No significant time trend in the prevalence of overall TDR was observed (p > 0.05). Conclusions We identified an intermediate prevalence of transmitted drug resistance (TDR), exhibiting a stable time trend. These findings enhance our understanding of HIV-1 drug resistance prevalence and time trend, and provide some guidelines for the comprehensive public health strategy of TDR prevention. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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