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Xiao-Yi Chen,1,* Guo-Qing Ru,2,* Ying-Yu Ma,1 Jun Xie,3 Wan-Yuan Chen,2 Hui-Ju Wang,1 Shi-Bing Wang,1 Li Li,1 Ke-Tao Jin,4 Xiang-Lei He,2 Xiao-Zhou Mou1 1Clinical Research Institute, 2Department of Pathology, Zhejiang Provincial People’s Hospital, Hangzhou, 3Department of Anus-Intestines, Affiliated Hospital of Shaoxing University, 4Department of Gastrointestinal Surgery, Shaoxing People’s Hospital, Shaoxing Hospital of Zhejiang University, Shaoxing, People’s Republic of China *These authors contributed equally to this work Background: Epidemiologic evidence suggests that chronic inflammation and/or chronic infection is associated with cancer development, and the inflammatory process may play a crucial role in the carcinogenesis and prognosis of colorectal cancer (CRC). Substance P (SP) belongs to the family of tachykinins and acts as an immunomodulator, binding to the neurokinin-1 receptor (NK1R) to initiate tumor cell proliferation, angiogenesis, and migration, steps that are critical for tumor cell invasion and metastasis. It is suggested that SP/NK1R signaling may play an important role in cancer progression and metastasis. However, the exact involvement and significance of SP and NK1R in CRC pathologies remain to be adequately deciphered.Patients and methods: We performed immunohistochemistry staining on tissue microarrays containing 267 pairs of CRC and adjacent normal tissues to evaluate the clinical significance of SP or NK1R in the progression and prognosis of CRC. We also explored the potential correlation between SP and NK1R in CRC development.Results: Expression levels of SP and NK1R were upregulated in CRC compared with their expressions in adjacent normal tissues (P |
