Rapid COVID-19 Screening Based on Self-Reported Symptoms: Psychometric Assessment and Validation of the EPICOVID19 Short Diagnostic Scale

Autor: Bastiani, Luca, Fortunato, Loredana, Pieroni, Stefania, Bianchi, Fabrizio, Adorni, Fulvio, Prinelli, Federica, Giacomelli, Andrea, Pagani, Gabriele, Maggi, Stefania, Trevisan, Caterina, Noale, Marianna, Jesuthasan, Nithiya, Sojic, Aleksandra, Pettenati, Carla, Andreoni, Massimo, Antonelli Incalzi, Raffaele, Galli, Massimo, Molinaro, Sabrina
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Journal of Medical Internet Research, Vol 23, Iss 1, p e23897 (2021)
Druh dokumentu: article
ISSN: 1438-8871
DOI: 10.2196/23897
Popis: BackgroundConfirmed COVID-19 cases have been registered in more than 200 countries, and as of July 28, 2020, over 16 million cases have been reported to the World Health Organization. This study was conducted during the epidemic peak of COVID-19 in Italy. The early identification of individuals with suspected COVID-19 is critical in immediately quarantining such individuals. Although surveys are widely used for identifying COVID-19 cases, outcomes, and associated risks, no validated epidemiological tool exists for surveying SARS-CoV-2 infection in the general population. ObjectiveWe evaluated the capability of self-reported symptoms in discriminating COVID-19 to identify individuals who need to undergo instrumental measurements. We defined and validated a method for identifying a cutoff score. MethodsOur study is phase II of the EPICOVID19 Italian national survey, which launched in April 2020 and included a convenience sample of 201,121 adults who completed the EPICOVID19 questionnaire. The Phase II questionnaire, which focused on the results of nasopharyngeal swab (NPS) and serological tests, was mailed to all subjects who previously underwent NPS tests. ResultsOf 2703 subjects who completed the Phase II questionnaire, 694 (25.7%) were NPS positive. Of the 472 subjects who underwent the immunoglobulin G (IgG) test and 421 who underwent the immunoglobulin M test, 22.9% (108/472) and 11.6% (49/421) tested positive, respectively. Compared to NPS-negative subjects, NPS-positive subjects had a higher incidence of fever (421/694, 60.7% vs 391/2009, 19.5%; P
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