| Autor: |
Tsugunobu Andoh, Yuichi Yageta, Mitsuhiro Konno, Tomomi Yamaguchi-Miyamoto, Hiroki Takahata, Hiroshi Nojima, Hideo Nemoto, Yasushi Kuraishi |
| Jazyk: |
angličtina |
| Rok vydání: |
2008 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 106, Iss 4, Pp 667-670 (2008) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.08004SC |
| Popis: |
The common adverse effect of centrally-injected μ-opioid receptor (μ-OR) agonists is pruritus. This study was conducted using mice to examine whether different subtypes of μ-OR would be responsible for pruritus and analgesia. Intracisternal injections of morphine and morphine-6β-glucronide (M6G), but not M3G, produced an antinociceptive effect. Morphine, but neither M6G nor M3G, induced facial scratching, a pruritus-related response. Facial scratching following morphine was not affected by the μ 1-OR antagonist naloxonazine at doses that inhibited the antinociceptive effects. The results suggest that different subtype and/or splice variants of μ-OR are separately involved in pruritus and antinociception of opioids. Keywords:: morphine, morphine-6β-glucronide, itch |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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