The Use of Mean Platelet Volume, Plateletcrit, and N-terminal Brain Natriuretic Peptide as Biomarkers of Coronary Artery Involvement in Atypical Kawasaki Disease

Autor: Eser Doğan, Caner Turan, Ali Yurtseven, Gamze Eman, Eylem Ulaş Saz
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Behçet Uz Children's Hospital, Vol 13, Iss 1, Pp 30-36 (2023)
Druh dokumentu: article
ISSN: 2822-4469
DOI: 10.4274/buchd.galenos.2022.75002
Popis: Objective: Coronary artery aneurysm and ectasia develop in approximately 15% to 25% of children with untreated Kawasaki disease (KD). Atypical KD has a higher incidence of coronary artery involvement compared to typical KD. Our aim in this study was to identify new markers to support early diagnosis and prevent complications associated with delayed treatment in atypical KD. Method: The patients' demographic characteristics, presenting complaints, clinical findings, mean platelet volume (MPV), plateletcrit (PCT), and N-terminal brain natriuretic peptide (NT-proBNP) levels were analyzed. Coronary artery abnormalities were evaluated using two-dimensional echocardiography. Results are expressed as mean (+- standard deviation). Results: Sixty children between the ages of 3 and 96 months who were diagnosed with atypical KD were included. Forty consecutive normal children were included as a control group. NT-proBNP, MPV, and PCT values were 381.7 (+-272.7) pg/mL, 5.8 (+-0.93) fL, and 0.266% (+-0.92%) in the patient group and 48.5 (+-28.5) pg/mL, 8.29 (+-1.12) fL, and 0.227% (+-0.78%) in the control group, respectively (p
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