Genetic influences on brain and cognitive health and their interactions with cardiovascular conditions and depression

Autor: Peter Zhukovsky, Earvin S. Tio, Gillian Coughlan, David A. Bennett, Yanling Wang, Timothy J. Hohman, Diego A. Pizzagalli, Benoit H. Mulsant, Aristotle N. Voineskos, Daniel Felsky
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-024-49430-7
Popis: Abstract Approximately 40% of dementia cases could be prevented or delayed by modifiable risk factors related to lifestyle and environment. These risk factors, such as depression and vascular disease, do not affect all individuals in the same way, likely due to inter-individual differences in genetics. However, the precise nature of how genetic risk profiles interact with modifiable risk factors to affect brain health is poorly understood. Here we combine multiple data resources, including genotyping and postmortem gene expression, to map the genetic landscape of brain structure and identify 367 loci associated with cortical thickness and 13 loci associated with white matter hyperintensities (P
Databáze: Directory of Open Access Journals
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