The effect of aqueous extracts of Anethum graveolens L. on amygdala kindled in rats
| Jazyk: | angličtina |
|---|---|
| Rok vydání: | 2018 |
| Předmět: | |
| Zdroj: | Journal of Medicinal Plants, Vol 17, Iss 68, Pp 41-48 (2018) |
| Druh dokumentu: | article |
| ISSN: | 2717-204X 2717-2058 |
| Popis: | Background: Electrical kindling model is common models to create epilepsy of temporal lobe. Although hydro-alcoholic extracts of Anethum graveolens L. had Anticonvulsants effect on PTZ-induced kindling seizure behavior, but on the amygdala kindling in rats induced seizure has not been investigated. Objective: In this study, we evaluated the chronic effects of hydro-alcoholic extracts of Anethum graveolens L. on seizures using electrical amygdala kindling model. Methods: Rats were divided into six groups. They were kindled by stimulating the amygdala by consecutive daily. Then, treated by hydro-alcoholic extracts of Anethum graveolens L. ( i.p. 100, 200 and 400 mg/kg) and cumulative After discharge Duration (ADD), Seizure Stage (SS) and Stage 5 seizure (S5D) were recorded. Results: Hydro-alcoholic extracts of Anethum graveolens L. (200 and 400 mg/kg) significantly increased stage 4 Latency compare to the vehicle group (p |
| Databáze: | Directory of Open Access Journals |
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