Association between monocyte to high-density lipoprotein cholesterol ratio and telomere length: based on NHANES 1999–2002

Autor: Haiyan Mao, Tong Lin, Shanshan Huang, Zhenye Xie, Jialu Chen, Xingkai Shen, Yi Ding, Guangze Xu, Zhikui Chen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: BMC Cardiovascular Disorders, Vol 24, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 1471-2261
DOI: 10.1186/s12872-024-04301-3
Popis: Abstract Background Telomere length is closely associated with the occurrence and development of cardiovascular and other diseases. Monocyte to high-density lipoprotein cholesterol ratio (MHR) is a novel indicator of inflammation, oxidative stress, and metabolic syndrome, with some predictive ability for related disease risks in clinical practice. However, there is no research on the correlation between these two factors. Methods Using data from the National Health and Nutrition Examination Survey (NHANES) from 1999 to 2002, we conducted analysis and research on the correlation between MHR and telomere length using the Kruskal-Wallis H test, Spearman rank correlation analysis, and partial correlation analysis. Weighted linear regression analysis assessed the strength of the association between the two variables, while restricted cubic spline regression (RCS) explored potential nonlinear relationships between them. Results The results of correlation analysis showed that MHR levels were negatively correlated with telomere length (ρ=-0.083, P
Databáze: Directory of Open Access Journals