Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp.

Autor: Birthe Sandargo, Leon Kaysan, Rémy B. Teponno, Christian Richter, Benjarong Thongbai, Frank Surup, Marc Stadler
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 1385-1391 (2021)
Druh dokumentu: article
ISSN: 1860-5397
DOI: 10.3762/bjoc.17.97
Popis: A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin (1), fulvoferruginins B–F (2–6). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.
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