Clinical characteristics of the BREATHE cohort – a real-life study on patients with asthma and COPD

Autor: Vibeke Backer, Ditte K. Klein, Uffe Bodtger, Kerstin Romberg, Celeste Porsbjerg, Jonas S. Erjefält, Karsten Kristiansen, Ruiqi Xu, Alexander Silberbrandt, Laurits Frøssing, Morten Hvidtfeldt, Nicolai Obling, Linnea Jarenbäck, Abir Nasr, Ellen Tufvesson, Michiko Mori, Matilde Winther-Jensen, Lisa Karlsson, Ulf Nihlén, Thomas Veje Flintegaard, Leif Bjermer
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: European Clinical Respiratory Journal, Vol 7, Iss 1 (2020)
Druh dokumentu: article
ISSN: 2001-8525
20018525
DOI: 10.1080/20018525.2020.1736934
Popis: Background: The BREATHE study is a cross-sectional study of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities and combinations of obstructive airway disease. Design: Patients with suspicion of asthma and/or COPD and healthy controls were invited to participate in the study and had a standard evaluation performed consisting of questionnaires, physical examination, FeNO and lung function, mannitol provocation test, allergy test, and collection of sputum and blood samples. A subgroup of patients and healthy controls had a bronchoscopy performed with a collection of airway samples. Results: The study population consisted of 1403 patients with obstructive airway disease (859 with asthma, 271 with COPD, 126 with concurrent asthma and COPD, 147 with other), and 89 healthy controls (smokers and non-smokers). Of patients with asthma, 54% had moderate-to-severe disease and 46% had mild disease. In patients with COPD, 82% had groups A and B, whereas 18% had groups C and D classified disease. Patients with asthma more frequently had childhood asthma, atopic dermatitis, and allergic rhinitis, compared to patients with COPD, asthma + COPD and Other, whereas FeNO levels were higher in patients with asthma and asthma + COPD compared to COPD and Other (18 ppb and 16 ppb vs 12.5 ppb and 14 ppb, p
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