Molecular Epidemiology of HIV-1 in Ghana: Subtype Distribution, Drug Resistance and Coreceptor Usage

Autor: Anna Appah, Charlotte J. Beelen, Don Kirkby, Winnie Dong, Aniqa Shahid, Brian Foley, Miriam Mensah, Vincent Ganu, Peter Puplampu, Linda E. Amoah, Nicholas I. Nii-Trebi, Chanson J. Brumme, Zabrina L. Brumme
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Viruses, Vol 15, Iss 1, p 128 (2022)
Druh dokumentu: article
ISSN: 1999-4915
DOI: 10.3390/v15010128
Popis: The greatest HIV-1 genetic diversity is found in West/Central Africa due to the pandemic’s origins in this region, but this diversity remains understudied. We characterized HIV-1 subtype diversity (from both sub-genomic and full-genome viral sequences), drug resistance and coreceptor usage in 103 predominantly (90%) antiretroviral-naive individuals living with HIV-1 in Ghana. Full-genome HIV-1 subtyping confirmed the circulating recombinant form CRF02_AG as the dominant (53.9%) subtype in the region, with the complex recombinant 06_cpx (4%) present as well. Unique recombinants, most of which were mosaics containing CRF02_AG and/or 06_cpx, made up 37% of sequences, while “pure” subtypes were rare (
Databáze: Directory of Open Access Journals
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