| Autor: |
Peter K. Moon, Jason Z. Qian, Emily McKenna, Kevin Xi, Nathan C. Rowe, Nathan N. Ng, Jimmy Zheng, Lydia T. Tam, Sarah J. MacEachern, Iram Ahmad, Alan G. Cheng, Nils D. Forkert, Kristen W. Yeom |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 27, Iss , Pp 102328- (2020) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2020.102328 |
| Popis: |
Purpose: Sensorineural hearing loss (SNHL) is the most prevalent congenital sensory deficit in children. Information regarding underlying brain microstructure could offer insight into neural development in deaf children and potentially guide therapies that optimize language development. We sought to quantitatively evaluate MRI-based cerebral volume and gray matter microstructure children with SNHL. Methods & Materials: We conducted a retrospective study of children with SNHL who obtained brain MRI at 3 T. The study cohort comprised 63 children with congenital SNHL without known focal brain lesion or structural abnormality (33 males; mean age 5.3 years; age range 1 to 11.8 years) and 64 age-matched controls without neurological, developmental, or MRI-based brain macrostructure abnormality. An atlas-based analysis was used to extract quantitative volume and median diffusivity (ADC) in the following brain regions: cerebral cortex, thalamus, caudate, putamen, globus pallidus, hippocampus, amygdala, nucleus accumbens, brain stem, and cerebral white matter. SNHL patients were further stratified by severity scores and hearing loss etiology. Results: Children with SNHL showed higher median ADC of the cortex (p = .019), thalamus (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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